ELEVATED RNA
SOLUTIONS
Heidolph North America provides novel solutions to industry scientists in the R&D, process development, manufacturing, and life science space. We can help with equipment for synthesis of RNA, oligonucleotides, bioconjugates, and small molecules. We also offer innovative solutions for smart cell cultivation, liquid sterilization, and process automation.
PROCESS DEVELOPMENT
MYA 4 - FOUR ZONE BIOREACTOR
Research and Development tools to optimize IVT reactions from 2mL to 400mL. Four independent zones of precise temperature control, overhead stirring, data-logging and pH control.
RNA MANUFACTURING
REACTOR-READY - BIOREACTOR SOLUTIONS
Manufacturing tools to produce RNA on a larger scale. Offering reactors with volumes from 100mL-35L. We can provide expertise on turnkey reactor setups for use in GMP facilities.
STERILIZATION
LAB-LINE BENCH-TOP AUTOCLAVES
The 3870 series steam autoclaves are indeed a proven and reliable choice for effectively sterilizing glass and stainless steel vessels between uses to prevent contamination. These autoclaves offer a range of features that make them well-suited for this application.
SIMPLIFING mRNA PRODUCTION
WITH VERSATILE REACTION SYSTEMS
Decades of research led to breakthroughs in mRNA vaccine development, notably in the 2000s with lipid nanoparticle delivery systems. The approval of the first mRNA vaccine in 2020 marked a pivotal moment in vaccine history, showcasing its rapid response capability. Solutions like the Mya 4 Reaction station and Reactor-Ready system address scaling challenges, ensuring consistent and high-quality mRNA output from lab to industrial-scale production. Download our white paper to learn more about optimizing mRNA production.
MEETING RNA DEMAND
This piece highlights the surging demand for mRNA-based therapies and the need for improved production techniques. It outlines Aldevron's expansion of mRNA manufacturing via collaboration and underscores the challenge of reducing impurities in longer mRNA strands. Achieving high-quality mRNA necessitates optimizing purification processes, and the industry is actively streamlining production to meet growing demand for various medical treatments.
BIOCHEMICAL REACTORS FOR IVT SCALE-UP & RNA MANUFACTURING
Our Reactor- Ready and Reactor-Ready Pilot systems for IVT reactions and RNA production. Our reactors are popular among researchers and contract manufacturers thanks to the precise temperature control, tool-free vessel interchange and geometric consistency between vessel sizes (1.25:1 aspect ratio). Another benefit of the Reactor Ready system is the ease of assembly and disassembly, allowing easy cleaning pre- and post- run.
DISTIMATIC & SOLVENT REMOVAL IN LIPID SYNTHESIS
HEI-VOLUME DISTIMATIC PRO & HEI-VAP ULTIMATE CONTROL
Hei-VAP Ultimate Control fully integrates your evaporation, vacuum, and chiller to provide increased consistency and precision in your evaporation process. Its solvent library provides pre-optimized evaporation parameters for solvent removal in Lipid synthesis. The Hei-VOLUME Distimatic Pro is an automation module that can attach to your evaporator to scale up and create a hands-free evaporation procedure.
FAST TO DEVELOP AUTOMATION
HEI-PROCESS AUTOMATION SOFTWARE
Hei-PROCESS is a next generation automation solution that brings a whole different level of connectivity to the workplace. The Hei-PROCESS is able to integrate any instrument with a digital interface and from there the user can create custom automations scripts to fit any demand, no matter how complex or simple they are. Remotely control your process through temperature, pH control, and data logging. View your reaction progress in real time from outside the lab or GMP manufacturing suite.
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